Probiotics to Help Prevent Cancer with Proper Gut Bacteria 

McKinney Chiropractor Best Practices

Research Commentary;

Prevent Cancer with Proper Gut Bacteria

A review of
Yoon, Youngmin, et al. “Bifidobacterium Strain-Specific enhances the efficacy of cancer therapeutics in tumor-bearing mice.” Cancers 13.5 (2021): 957
By Dr. Bryan Stephens

Proper Gut Bacteria 

Summarized Review Conclusions

The addition of specific strains of Bifidobacterium breve (probiotics) not only assisted with antitumor properties in the gut against colorectal cancer, but one strain also showed the ability to increase the efficacy of current cancer therapies used to treat the cancer.  They induced anti-tumor immunity and showed decreased tumor growth and increased lymphocyte mediated anti-cancer immunity.  Essentially, having the proper gut bacteria helped cut down tumor size and aided with cancer therapies to fight the colon cancer in mice.

 

“Previous studies have shown that dysbiosis of the gut microbiome affects cancer development, because it leads to inflammation and genotoxicity.”

Yoon, Youngmin, et al. “Bifidobacterium Strain-Specific enhances the efficacy of cancer therapeutics in tumor-bearing mice.” Cancers 13.5 (2021): 957

“we observed that supplementation with either of two B. breve strains reduces tumor growth in MC38 colon carcinoma-bearing mice”

Yoon, Youngmin, et al. “Bifidobacterium Strain-Specific enhances the efficacy of cancer therapeutics in tumor-bearing mice.” Cancers 13.5 (2021): 957

“The gut microbiome affects immune system development and differentiation by regulating innate immune responses, including innate lymphoid cells and gene expression”

Yoon, Youngmin, et al. “Bifidobacterium Strain-Specific enhances the efficacy of cancer therapeutics in tumor-bearing mice.” Cancers 13.5 (2021): 957

 

Introduction to the Research

Cancer is one of the major killers in the world and colorectal cancers are among the leading types of cancer-related deaths.  Colorectal cancers are found to be highly associated with smoking, poor diet, and gut dysbiosis, or improper bacteria in the gut.  These things add to gut inflammation along with genetic and epigenetic alterations which increase the frequency of adenomas and carcinomas.  Previous studies have shown that having a proper microbiome cut down on the incidence of colorectal cancers, but this study went further and looked at the impact that B. breve had on the immune therapies used to treat colorectal cancer.

 

Research Methodology

Mice were split into groups with 2 groups being administered a strain of the B. breve bacteria for 14 days before being introduced to the colon adenocarcinoma cells.  The groups were then treated with oxaliplatin, a current treatment for colorectal cancer.  Tumor sizes were monitored 3 times per week for the duration of the study.

 

Research Findings

The addition of the B. breve strains increased the innate anti-tumor effects in the mice.  One strain, the B. breve JCM92 strain, also increased the efficacy of the oxaliplatin by enhancing anti-tumor immunity.

“Here, we found that Bifidobacterium strains confer anti-tumor properties. Although two B. breve strains increased anti-tumor immunity, only one B. breve strain boosted cancer therapeutic efficacy. Immune cell profiling of spleen and tumor tissue revealed that B. breve strains alone augmented anti-tumor immunity by increasing CD8+ T and effector CD8+ T cell numbers, and by increasing the CD8+/Treg and effector CD8+/Treg ratio. However, only B. breve JCM92 boosted the efficacy of cancer therapeutics.”

Yoon, Youngmin, et al. “Bifidobacterium Strain-Specific enhances the efficacy of cancer therapeutics in tumor-bearing mice.” Cancers 13.5 (2021): 957

 

Research References

As always with these reviews, these are my takeaways from the article and I encourage you to read the article in its entirety.  The references used in this article by the authors of this article are listed here.

 

Our Message

When you are looking for a Chiropractor near you that you can trust, choose one who will not only help you avoid back pain while sitting but who will also guide you to living a healthier lifestyle to keep you out of pain. Our Chiropractors, located near West Ridge, near the corner of S. Stonebridge Dr. and Eldorado Pkwy, will teach you what the research says about Proper Gut Bacteria and why we should eat a better diet, move more and have more positive thoughts.